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European Journal of Clinical Microbiology and Infectious Diseases 25(1):39–42. By maintaining a small amount of amide substitution, this allowed the identification of UK-484900, the original clinical candidate follow-up compound to maraviroc, and then PF-232798 (Scheme 1). The reproducibility of pyrolysis gas-liquid chromatography (PGLC) suffers from column ageing and inconsistency between columns, and even pyrolysis mass spectrometry (PMS) equipment can be subject to drift. Antiport structures move two or more substances across the cell membrane in different directions.

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Small proteins have few completely buried residues and only ~15% of the residues are totally inaccessible to solvent in large proteins.